| Guatemala - Reserveliga | 2022/04/23 21:00 | Xelaju - Reserve v Santa Lucia FC - Reserve | D | 1-1 |
| Guatemala - Reserveliga | 2022/04/20 20:15 | Santa Lucia FC - Reserve v Malacateco - Reserve | W | 1-0 |
| Guatemala - Reserveliga | 2022/04/10 20:00 | Santa Lucia FC - Reserve v Solola FC Reserves | W | 5-0 |
| Guatemala - Reserveliga | 2022/04/02 19:00 | Guastatoya - Reserve v Santa Lucia FC - Reserve | L | 2-1 |
| Guatemala - Reserveliga | 2022/03/27 17:00 | Antigua GFC - Reserve v Santa Lucia FC - Reserve | W | 0-1 |
| Guatemala - Reserveliga | 2022/02/09 20:28 | Santa Lucia FC - Reserve v CSD Comunicaciones - Reserve | W | 6-3 |
| Guatemala - Reserveliga | 2022/02/06 20:00 | CSD Sololá - Reserve v Santa Lucia FC - Reserve | L | 2-1 |
| Guatemala - Reserveliga | 2022/01/16 16:00 | Santa Lucia FC - Reserve v CSD Municipal - Reserve | L | 0-1 |
| Guatemala - Reserveliga | 2022/04/17 18:00 | Nueva Concepcion Reserves v Deportivo Iztapa - Reserve | L | 0-3 |
| Guatemala - Reserveliga | 2022/04/02 16:00 | Nueva Concepcion Reserves v Antigua GFC - Reserve | L | 0-1 |
| Guatemala - Reserveliga | 2022/03/27 18:00 | Nueva Concepcion Reserves v Xelaju - Reserve | L | 2-4 |
| Guatemala - Reserveliga | 2022/02/09 18:00 | Deportivo Iztapa - Reserve v Nueva Concepcion Reserves | L | 6-3 |