| NCAAF | 11/11 18:30 | 1 | Otterbein Cardinals v John Carroll Blue Streaks | L | 22-37 | |
| NCAAF | 11/04 17:30 | 1 | Ohio Northern Polar Bears v Otterbein Cardinals | L | 49-6 | |
| NCAAF | 10/28 17:30 | 1 | Mount Union v Otterbein Cardinals | L | 51-14 | |
| NCAAF | 10/21 16:30 | 1 | Otterbein Cardinals v Baldwin Wallace Yellow Jackets | L | 0-24 | |
| NCAAF | 10/14 21:00 | 1 | Heidelberg Student Princes v Otterbein Cardinals | L | 28-8 | |
| NCAAF | 09/30 17:30 | 1 | Capital Crusaders v Otterbein Cardinals | L | 35-31 | |
| NCAAF | 09/23 17:30 | 1 | Marietta Pioneers v Otterbein Cardinals | L | 50-0 | |
| NCAAF | 09/16 19:00 | 1 | Otterbein Cardinals v Wilmington Quakers | L | 21-47 | |
| NCAAF | 09/09 16:00 | 1 | Otterbein Cardinals v Muskingum Muskies | L | 14-27 | |
| NCAAF | 09/02 16:00 | 1 | Otterbein Cardinals v Ohio Wesleyan Battling Bishops | L | 21-35 | |
| NCAAF | 11/12 18:30 | 1 | John Carroll Blue Streaks v Otterbein Cardinals | L | 62-7 | |
| NCAAF | 11/05 17:30 | 1 | Otterbein Cardinals v Ohio Northern Polar Bears | L | 7-42 | |
| NCAAF | 10/29 18:00 | 1 | Otterbein Cardinals v Mount Union | L | 0-59 | |
| NCAAF | 10/22 18:00 | 1 | Baldwin Wallace Yellow Jackets v Otterbein Cardinals | L | 35-14 | |
| NCAAF | 10/08 17:30 | 1 | Muskingum Muskies v Otterbein Cardinals | L | 41-35 | |
| NCAAF | 10/01 18:00 | 1 | Otterbein Cardinals v Capital Crusaders | W | 35-28 | |
| NCAAF | 09/24 18:00 | 1 | Otterbein Cardinals v Marietta Pioneers | L | 10-27 | |
| NCAAF | 09/17 18:00 | 1 | Wilmington Quakers v Otterbein Cardinals | L | 32-26 | |
| NCAAF | 09/10 16:00 | 1 | Otterbein Cardinals v Heidelberg Student Princes | L | 7-34 | |
| NCAAF | 09/03 18:00 | 1 | Ohio Wesleyan Battling Bishops v Otterbein Cardinals | W | 13-21 | |
| NCAAF | 11/13 18:30 | 1 | Otterbein Cardinals v Wilmington Quakers | L | 33-37 | |
| NCAAF | 11/06 17:30 | 1 | Marietta Pioneers v Otterbein Cardinals | L | 56-7 | |
| NCAAF | 10/30 17:30 | 1 | Capital Crusaders v Otterbein Cardinals | W | 33-38 | |
| NCAAF | 10/23 18:00 | 1 | Otterbein Cardinals v Muskingum Muskies | L | 14-31 | |
| NCAAF | 10/16 23:00 | 1 | Heidelberg Student Princes v Otterbein Cardinals | L | 52-19 | |
| NCAAF | 10/02 17:30 | 1 | Mount Union v Otterbein Cardinals | L | 55-0 | |
| NCAAF | 09/25 17:30 | 1 | Ohio Northern Polar Bears v Otterbein Cardinals | L | 56-7 | |
| NCAAF | 09/18 18:00 | 1 | Otterbein Cardinals v John Carroll Blue Streaks | L | 17-41 | |
| NCAAF | 09/11 17:30 | 1 | Otterbein Cardinals v Baldwin Wallace Yellow Jackets | L | 10-41 | |
| NCAAF | 09/04 16:00 | 1 | Otterbein Cardinals v Ohio Wesleyan Battling Bishops | L | 28-32 |