[4] Tigres UANL 1-0 Santos Laguna [5] 2021-11-29 00:00
Stadion: Estadio Universitario Round: 3
Schiedsrichter: Luis Enrique Santander Aguirre Home Manager: Miguel Herrera Away Manager: Guillermo Almada
Head to Head
| Mexiko - Liga MX | 2021/11/26 03:05 | Santos Laguna v Tigres UANL | L | 2-1 |
| Mexiko - Liga MX | 2021/08/08 02:00 | Tigres UANL v Santos Laguna | D | 1-1 |
| Mexiko - Liga MX | 2021/01/18 01:06 | Santos Laguna v Tigres UANL | L | 2-0 |
| Mexiko - Liga MX | 2020/09/13 00:00 | Tigres UANL v Santos Laguna | W | 2-0 |
| Mexiko - Liga MX | 2020/02/17 00:45 | Santos Laguna v Tigres UANL | L | 2-1 |
| Mexiko - Liga MX | 2019/10/06 00:00 | Tigres UANL v Santos Laguna | W | 4-0 |
| CONCACAF Champions Cup | 2019/04/11 00:00 | Santos Laguna v Tigres UANL | L | 3-2 |
| CONCACAF Champions Cup | 2019/04/04 02:00 | Tigres UANL v Santos Laguna | W | 3-0 |
Home History
| Mexiko - Liga MX | 2021/11/26 03:05 | Santos Laguna v Tigres UANL | L | 2-1 |
| Mexiko - Liga MX | 2021/11/07 03:00 | Tigres UANL v Juarez FC | W | 3-0 |
| Mexiko - Liga MX | 2021/10/31 02:10 | Tigres UANL v Chivas Guadalajara | W | 2-1 |
| Mexiko - Liga MX | 2021/10/24 00:00 | Club America v Tigres UANL | L | 1-0 |
| Mexiko - Liga MX | 2021/10/21 02:00 | Tigres UANL v Pachuca | W | 3-0 |
| Mexiko - Liga MX | 2021/10/17 02:00 | Cruz Azul v Tigres UANL | D | 1-1 |
| Mexiko - Liga MX | 2021/10/04 00:00 | Tigres UANL v Necaxa | D | 0-0 |
| Mexiko - Liga MX | 2021/09/29 22:00 | Atletico San Luis v Tigres UANL | W | 0-3 |
Away History
| Mexiko - Liga MX | 2021/11/26 03:05 | Santos Laguna v Tigres UANL | W | 2-1 |
| Mexiko - Liga MX | 2021/11/21 01:00 | Santos Laguna v Atletico San Luis | W | 2-0 |
| Mexiko - Liga MX | 2021/11/08 01:06 | Santos Laguna v Atletico San Luis | D | 0-0 |
| Mexiko - Liga MX | 2021/11/05 01:00 | Unam Pumas v Santos Laguna | W | 0-3 |
| Mexiko - Liga MX | 2021/10/30 22:00 | Queretaro v Santos Laguna | W | 2-3 |
| Mexiko - Liga MX | 2021/10/25 00:06 | Santos Laguna v Toluca | D | 2-2 |
| Mexiko - Liga MX | 2021/10/20 00:05 | Club America v Santos Laguna | L | 2-1 |
| Mexiko - Liga MX | 2021/10/17 00:00 | Pachuca v Santos Laguna | D | 1-1 |