[18] Toluca 3-1 Santos Laguna [11] 2022-01-16 18:00
Stadion: Estadio Nemesio Diez Round: 2
Schiedsrichter: Cesar Arturo Ramos Home Manager: Hernan Cristante Away Manager: Pedro Caixinha
Head to Head
| Mexiko - Liga MX | 2021/10/25 00:06 | Santos Laguna v Toluca | D | 2-2 |
| Mexiko - Liga MX | 2021/04/19 00:00 | Santos Laguna v Toluca | L | 3-1 |
| Mexiko - Liga MX | 2020/09/20 17:00 | Toluca v Santos Laguna | L | 1-2 |
| Mexiko - Liga MX | 2019/11/24 18:00 | Toluca v Santos Laguna | D | 2-2 |
| Mexiko - Liga MX | 2019/02/25 00:06 | Santos Laguna v Toluca | L | 4-0 |
| Mexiko - Liga MX | 2018/09/02 17:00 | Toluca v Santos Laguna | W | 2-1 |
| Mexiko - Liga MX | 2018/05/21 00:00 | Toluca v Santos Laguna | D | 1-1 |
| Mexiko - Liga MX | 2018/05/18 01:00 | Santos Laguna v Toluca | L | 2-1 |
Home History
| Mexiko - Liga MX | 2022/01/11 03:00 | Unam Pumas v Toluca | L | 5-0 |
| Mexiko - Liga MX | 2021/11/21 23:00 | Toluca v Unam Pumas | L | 1-2 |
| Mexiko - Liga MX | 2021/11/06 01:00 | Puebla v Toluca | L | 1-0 |
| Mexiko - Liga MX | 2021/10/31 18:00 | Toluca v Leon | D | 0-0 |
| Mexiko - Liga MX | 2021/10/25 00:06 | Santos Laguna v Toluca | D | 2-2 |
| Mexiko - Liga MX | 2021/10/21 00:00 | Toluca v Necaxa | D | 1-1 |
| Mexiko - Liga MX | 2021/10/17 22:00 | Chivas Guadalajara v Toluca | L | 2-0 |
| Mexiko - Liga MX | 2021/10/03 17:00 | Toluca v Queretaro | D | 1-1 |
Away History
| Mexiko - Liga MX | 2022/01/13 02:06 | Santos Laguna v Tigres UANL | D | 1-1 |
| Mexiko - Liga MX | 2021/11/29 00:00 | Tigres UANL v Santos Laguna | L | 1-0 |
| Mexiko - Liga MX | 2021/11/26 03:05 | Santos Laguna v Tigres UANL | W | 2-1 |
| Mexiko - Liga MX | 2021/11/21 01:00 | Santos Laguna v Atletico San Luis | W | 2-0 |
| Mexiko - Liga MX | 2021/11/08 01:06 | Santos Laguna v Atletico San Luis | D | 0-0 |
| Mexiko - Liga MX | 2021/11/05 01:00 | Unam Pumas v Santos Laguna | W | 0-3 |
| Mexiko - Liga MX | 2021/10/30 22:00 | Queretaro v Santos Laguna | W | 2-3 |
| Mexiko - Liga MX | 2021/10/25 00:06 | Santos Laguna v Toluca | D | 2-2 |