[18] Santos Laguna 3-2 Unam Pumas [7] 2022-03-03 03:00
Stadion: Estadio TSM Corona Round: 8
Schiedsrichter: Oscar Macias Romo Home Manager: Pedro Caixinha Away Manager: Andres Lillini
Head to Head
| Mexiko - Liga MX | 2021/11/05 01:00 | Unam Pumas v Santos Laguna | W | 0-3 |
| Mexiko - Liga MX | 2021/03/05 03:00 | Unam Pumas v Santos Laguna | L | 1-0 |
| Mexiko - Liga MX | 2020/09/10 02:06 | Santos Laguna v Unam Pumas | L | 1-2 |
| Mexiko - Liga MX | 2020/02/02 03:00 | Santos Laguna v Unam Pumas | D | 1-1 |
| Mexiko - Pokal | 2020/01/30 01:00 | Unam Pumas v Santos Laguna | L | 2-1 |
| Mexiko - Pokal | 2020/01/23 03:00 | Santos Laguna v Unam Pumas | W | 4-2 |
| Mexiko - Liga MX | 2019/09/29 17:00 | Unam Pumas v Santos Laguna | L | 2-0 |
| Mexiko - Liga MX | 2019/05/05 23:06 | Santos Laguna v Unam Pumas | W | 5-2 |
Home History
| Mexiko - Liga MX | 2022/02/28 01:00 | Cruz Azul v Santos Laguna | W | 1-2 |
| CONCACAF Champions Cup | 2022/02/24 01:15 | CF Montreal v Santos Laguna | L | 3-0 |
| Mexiko - Liga MX | 2022/02/19 03:00 | Juarez FC v Santos Laguna | D | 0-0 |
| CONCACAF Champions Cup | 2022/02/16 03:00 | Santos Laguna v CF Montreal | W | 1-0 |
| Mexiko - Liga MX | 2022/02/13 03:00 | Santos Laguna v Club America | L | 2-3 |
| Mexiko - Liga MX | 2022/02/07 00:00 | Atlas v Santos Laguna | L | 2-1 |
| Freundschaftsspiele - Europa | 2022/01/29 02:00 | Mazatlan FC v Santos Laguna | L | 2-1 |
| Mexiko - Liga MX | 2022/01/24 01:00 | Santos Laguna v Necaxa | L | 1-4 |
Away History
| Mexiko - Liga MX | 2022/02/27 03:00 | Unam Pumas v Club America | D | 0-0 |
| CONCACAF Champions Cup | 2022/02/24 03:30 | Unam Pumas v Deportivo Saprissa | W | 4-1 |
| Mexiko - Liga MX | 2022/02/21 02:00 | Atlas v Unam Pumas | D | 0-0 |
| CONCACAF Champions Cup | 2022/02/17 03:00 | Deportivo Saprissa v Unam Pumas | D | 2-2 |
| Mexiko - Liga MX | 2022/02/13 18:00 | Unam Pumas v Leon | W | 2-1 |
| Mexiko - Liga MX | 2022/02/06 03:06 | Tijuana v Unam Pumas | L | 1-0 |
| Mexiko - Liga MX | 2022/01/23 18:00 | Unam Pumas v Tigres UANL | L | 1-2 |
| Mexiko - Liga MX | 2022/01/15 01:00 | Queretaro v Unam Pumas | W | 1-3 |