[9] Atletico San Luis 1-3 Santos Laguna [15] 2022-05-01 21:00
Stadion: Estadio Alfonso Lastras Ramirez Round: 17
Schiedsrichter: Ismael Rosario Lopez Penuelas Home Manager: Andre Jardine Away Manager: Eduardo Fentanes
Head to Head
| Mexiko - Liga MX | 2021/11/21 01:00 | Santos Laguna v Atletico San Luis | L | 2-0 |
| Mexiko - Liga MX | 2021/11/08 01:06 | Santos Laguna v Atletico San Luis | D | 0-0 |
| Mexiko - Liga MX | 2021/02/19 03:00 | Atletico San Luis v Santos Laguna | W | 1-0 |
| Mexiko - Liga MX | 2020/10/26 01:06 | Santos Laguna v Atletico San Luis | L | 2-1 |
| Mexiko - Liga MX | 2019/09/21 22:00 | Atletico San Luis v Santos Laguna | L | 2-3 |
| Mexiko - Pokal | 2015/02/18 01:00 | Santos Laguna v Atletico San Luis | L | 3-0 |
| Mexiko - Pokal | 2015/02/04 03:00 | Atletico San Luis v Santos Laguna | D | 0-0 |
| Mexiko - Pokal | 2014/08/06 00:00 | Santos Laguna v Atletico San Luis | D | 0-0 |
Home History
| Mexiko - Liga MX | 2022/04/24 22:00 | Cruz Azul v Atletico San Luis | W | 0-1 |
| Mexiko - Liga MX | 2022/04/21 00:00 | Atletico San Luis v Unam Pumas | W | 2-0 |
| Mexiko - Liga MX | 2022/04/16 00:00 | Necaxa v Atletico San Luis | L | 4-2 |
| Mexiko - Liga MX | 2022/04/09 22:00 | Atletico San Luis v Leon | W | 2-0 |
| Mexiko - Liga MX | 2022/04/07 02:06 | Tijuana v Atletico San Luis | D | 1-1 |
| Mexiko - Liga MX | 2022/04/02 02:00 | Atletico San Luis v Mazatlan FC | W | 1-0 |
| Mexiko - Liga MX | 2022/03/18 03:05 | Queretaro v Atletico San Luis | L | 2-1 |
| Mexiko - Liga MX | 2022/03/13 23:00 | Atletico San Luis v Puebla | W | 2-1 |
Away History
| Mexiko - Liga MX | 2022/04/25 00:00 | Santos Laguna v Leon | D | 1-1 |
| Mexiko - Liga MX | 2022/04/20 02:00 | Mazatlan FC v Santos Laguna | L | 1-0 |
| Mexiko - Liga MX | 2022/04/17 00:00 | Santos Laguna v Queretaro | D | 1-1 |
| Mexiko - Liga MX | 2022/04/10 00:06 | Monterrey v Santos Laguna | L | 1-0 |
| Mexiko - Liga MX | 2022/04/04 00:00 | Santos Laguna v Pachuca | W | 3-1 |
| Mexiko - Liga MX | 2022/03/19 03:00 | Puebla v Santos Laguna | D | 2-2 |
| Mexiko - Liga MX | 2022/03/14 01:00 | Santos Laguna v Tijuana | W | 4-0 |
| Mexiko - Liga MX | 2022/03/06 03:00 | Chivas Guadalajara v Santos Laguna | L | 1-0 |