| Guatemala - Reserveliga | 2022/04/20 20:15 | Santa Lucia FC - Reserve v Malacateco - Reserve | L | 1-0 |
| Guatemala - Reserveliga | 2022/05/04 21:14 | Malacateco - Reserve v CSD Comunicaciones - Reserve | L | 0-2 |
| Guatemala - Reserveliga | 2022/04/20 20:15 | Santa Lucia FC - Reserve v Malacateco - Reserve | L | 1-0 |
| Guatemala - Reserveliga | 2022/04/16 19:00 | Malacateco - Reserve v CD Achuapa - Reserve | W | 1-0 |
| Guatemala - Reserveliga | 2022/04/02 17:00 | Malacateco - Reserve v Deportivo Iztapa - Reserve | L | 0-2 |
| Guatemala - Reserveliga | 2022/03/26 16:00 | Coban Imperial - Reserve v Malacateco - Reserve | L | 3-0 |
| Guatemala - Reserveliga | 2022/02/09 18:00 | CD Achuapa - Reserve v Malacateco - Reserve | L | 2-1 |
| Guatemala - Reserveliga | 2022/02/06 21:00 | Malacateco - Reserve v CSD Municipal - Reserve | W | 2-0 |
| Guatemala - Reserveliga | 2022/01/30 21:00 | Malacateco - Reserve v Coban Imperial - Reserve | W | 2-0 |
| Guatemala - Reserveliga | 2022/05/04 16:11 | Coban Imperial - Reserve v Santa Lucia FC - Reserve | W | 0-1 |
| Guatemala - Reserveliga | 2022/04/30 21:20 | Santa Lucia FC - Reserve v Nueva Concepcion Reserves | W | 4-1 |
| Guatemala - Reserveliga | 2022/04/23 21:00 | Xelaju - Reserve v Santa Lucia FC - Reserve | D | 1-1 |
| Guatemala - Reserveliga | 2022/04/20 20:15 | Santa Lucia FC - Reserve v Malacateco - Reserve | W | 1-0 |
| Guatemala - Reserveliga | 2022/04/10 20:00 | Santa Lucia FC - Reserve v Solola FC Reserves | W | 5-0 |
| Guatemala - Reserveliga | 2022/04/02 19:00 | Guastatoya - Reserve v Santa Lucia FC - Reserve | L | 2-1 |
| Guatemala - Reserveliga | 2022/03/27 17:00 | Antigua GFC - Reserve v Santa Lucia FC - Reserve | W | 0-1 |
| Guatemala - Reserveliga | 2022/02/09 20:28 | Santa Lucia FC - Reserve v CSD Comunicaciones - Reserve | W | 6-3 |