[6] Toluca 4-3 Santos Laguna [3] 2022-10-14 00:06
Stadion: Estadio Nemesio Diez Round: 3
Schiedsrichter: Diego Montano Robles Home Manager: Marcos Ignacio Ambriz Away Manager: Eduardo Fentanes
Head to Head
| Mexiko - Liga MX | 2022/07/23 22:00 | Toluca v Santos Laguna | W | 2-1 |
| Mexiko - Liga MX | 2022/01/16 18:00 | Toluca v Santos Laguna | W | 3-1 |
| Mexiko - Liga MX | 2021/10/25 00:06 | Santos Laguna v Toluca | D | 2-2 |
| Mexiko - Liga MX | 2021/04/19 00:00 | Santos Laguna v Toluca | L | 3-1 |
| Mexiko - Liga MX | 2020/09/20 17:00 | Toluca v Santos Laguna | L | 1-2 |
| Mexiko - Liga MX | 2019/11/24 18:00 | Toluca v Santos Laguna | D | 2-2 |
| Mexiko - Liga MX | 2019/02/25 00:06 | Santos Laguna v Toluca | L | 4-0 |
| Mexiko - Liga MX | 2018/09/02 17:00 | Toluca v Santos Laguna | W | 2-1 |
Home History
| Mexiko - Liga MX | 2022/10/09 17:00 | Toluca v Juarez FC | W | 3-0 |
| Mexiko - Liga MX | 2022/10/02 17:00 | Toluca v Queretaro | W | 4-1 |
| Mexiko - Liga MX | 2022/09/17 02:00 | Mazatlan FC v Toluca | D | 1-1 |
| Mexiko - Liga MX | 2022/09/11 02:05 | Toluca v Unam Pumas | D | 2-2 |
| Mexiko - Liga MX | 2022/09/08 00:00 | Tigres UANL v Toluca | L | 3-1 |
| Mexiko - Liga MX | 2022/09/04 22:30 | Toluca v Chivas Guadalajara | D | 0-0 |
| Mexiko - Liga MX | 2022/08/28 17:00 | Toluca v Pachuca | L | 1-4 |
| Mexiko - Liga MX | 2022/08/21 22:00 | Atletico San Luis v Toluca | L | 1-0 |
Away History
| Mexiko - Liga MX | 2022/10/02 23:05 | Santos Laguna v Mazatlan FC | W | 3-0 |
| Mexiko - Liga MX | 2022/09/19 00:05 | Santos Laguna v Juarez FC | W | 2-0 |
| Mexiko - Liga MX | 2022/09/15 02:05 | Club America v Santos Laguna | D | 3-3 |
| Mexiko - Liga MX | 2022/09/10 22:00 | Queretaro v Santos Laguna | D | 3-3 |
| Mexiko - Liga MX | 2022/09/07 00:05 | Santos Laguna v Necaxa | W | 3-1 |
| Mexiko - Liga MX | 2022/09/03 22:05 | Pachuca v Santos Laguna | L | 2-0 |
| Mexiko - Liga MX | 2022/08/29 00:05 | Santos Laguna v Atletico San Luis | W | 4-1 |
| Mexiko - Liga MX | 2022/08/26 02:05 | Tijuana v Santos Laguna | W | 0-2 |