[2] Roger Federer 6-7,7-6,1-0 John Isner [10] 2018-09-23 18:30
Ground: Hardcourt indoor
Head to Head
| US Open | 2015/09/08 01:00 | John Isner v Roger Federer | 6-7,6-7,5-7 |
Home History
| Laver Cup | 2018/09/22 20:05 | Roger Federer v Nick Kyrgios | 6-3,6-2 |
| US Open | 2018/09/04 01:00 | John Millman v Roger Federer | 3-6,7-5,7-6,7-6 |
| US Open | 2018/09/01 18:05 | Nick Kyrgios v Roger Federer | 4-6,1-6,5-7 |
| US Open | 2018/08/30 18:45 | Benoit Paire v Roger Federer | 5-7,4-6,4-6 |
| US Open | 2018/08/28 23:00 | Yoshihito Nishioka v Roger Federer | 2-6,2-6,4-6 |
| ATP - Cincinnati | 2018/08/19 20:25 | Novak Djokovic v Roger Federer | 6-4,6-4 |
| ATP - Cincinnati | 2018/08/18 01:05 | Stan Wawrinka v Roger Federer | 7-6,6-7,2-6 |
| ATP - Cincinnati | 2018/08/17 18:00 | Leonardo Mayer v Roger Federer | 1-6,6-7 |
Away History
| Laver Cup | 2018/09/22 18:00 | Alexander Zverev v John Isner | 3-6,7-6,10-7 |
| US Open | 2018/09/04 17:45 | Juan Martin Del Potro v John Isner | 6-7,6-3,7-6,6-2 |
| US Open | 2018/09/02 19:45 | John Isner v Milos Raonic | 3-6,6-3,6-4,3-6,6-2 |
| US Open | 2018/08/31 21:00 | John Isner v Dusan Lajovic | 7-6,6-7,6-3,7-5 |
| US Open | 2018/08/29 20:45 | John Isner v Nicolas Jarry | 6-7,6-4,3-6,7-6,6-4 |
| US Open | 2018/08/27 16:50 | John Isner v Bradley Klahn | 7-6,6-3,6-4 |
| ATP - Cincinnati | 2018/08/13 20:15 | John Isner v Sam Querrey | 4-6,7-6,6-7 |
| ATP - Toronto | 2018/08/09 22:40 | Karen Khachanov v John Isner | 7-6,7-6 |