Home History
| NCAAF | 2005/12/03 12:00 | Connecticut v Louisville | W | 20-30 |
| NCAAF | 2005/11/26 12:00 | Louisville v Syracuse | W | 41-17 |
| NCAAF | 2005/11/11 12:00 | Louisville v Rutgers | W | 56-5 |
| NCAAF | 2005/11/03 12:00 | Louisville v Pittsburgh | W | 42-20 |
| NCAAF | 2005/10/22 12:00 | Cincinnati v Louisville | W | 22-46 |
| NCAAF | 2005/10/15 12:00 | West Virginia v Louisville | L | 46-44 |
| NCAAF | 2005/10/08 12:00 | Louisville v North Carolina | W | 69-14 |
| NCAAF | 2005/10/01 12:00 | Louisville v Florida Atlantic | W | 61-10 |
Away History
| NCAAF | 2005/12/03 12:00 | Florida State v Virginia Tech | L | 27-22 |
| NCAAF | 2005/11/26 12:00 | Virginia Tech v North Carolina | W | 30-3 |
| NCAAF | 2005/11/19 12:00 | Virginia v Virginia Tech | W | 14-52 |
| NCAAF | 2005/11/05 12:00 | Virginia Tech v Miami Florida | L | 7-27 |
| NCAAF | 2005/10/27 12:00 | Virginia Tech v Boston College | W | 30-10 |
| NCAAF | 2005/10/20 12:00 | Maryland v Virginia Tech | W | 9-28 |
| NCAAF | 2005/10/08 12:00 | Virginia Tech v Marshall | W | 41-14 |
| NCAAF | 2005/10/01 12:00 | West Virginia v Virginia Tech | W | 17-34 |