Stadion: Manning Field at John L. Guidry Stadium Round: 1
Home Manager: Tim Rebowe Away Manager: Frank Scelfo
| NCAAF | 2021/11/19 00:00 | Nicholls State v SE Louisiana | L | 45-42 |
| NCAAF | 2021/10/09 17:00 | SE Louisiana v Nicholls State | W | 58-48 |
| NCAAF | 2021/04/10 20:00 | SE Louisiana v Nicholls State | W | 52-45 |
| NCAAF | 2019/11/22 00:00 | Nicholls State v SE Louisiana | L | 28-27 |
| NCAAF FCS | 2018/11/16 00:00 | SE Louisiana v Nicholls State | L | 0-44 |
| NCAAF | 2017/11/17 00:00 | SE Louisiana v Nicholls State | W | 21-17 |
| NCAAF | 2022/11/12 22:00 | Northwestern State v SE Louisiana | W | 7-23 |
| NCAAF | 2022/11/05 20:00 | SE Louisiana v Lamar | W | 47-31 |
| NCAAF | 2022/10/30 00:00 | SE Louisiana v McNeese State | W | 28-27 |
| NCAAF | 2022/10/22 18:00 | SE Louisiana v Jacksonville State | W | 31-14 |
| NCAAF | 2022/10/08 21:00 | Texas A&M-Commerce v SE Louisiana | L | 31-28 |
| NCAAF | 2022/10/01 23:00 | Murray State v SE Louisiana | W | 14-48 |
| NCAAF | 2022/09/24 23:00 | Incarnate Word v SE Louisiana | W | 35-41 |
| NCAAF | 2022/09/17 23:00 | Central Connecticut v SE Louisiana | W | 6-70 |
| NCAAF | 2022/11/12 21:00 | Texas A&M-Commerce v Nicholls State | W | 10-12 |
| NCAAF | 2022/10/29 20:00 | Nicholls State v Lamar | L | 17-24 |
| NCAAF | 2022/10/22 20:00 | McNeese State v Nicholls State | W | 35-40 |
| NCAAF | 2022/10/15 20:00 | Incarnate Word v Nicholls State | L | 49-14 |
| NCAAF | 2022/10/08 23:00 | Nicholls State v Houston Christian | W | 19-17 |
| NCAAF | 2022/10/01 20:30 | Nicholls State v Northwestern State | L | 33-36 |
| NCAAF | 2022/09/24 20:00 | Jacksonville State v Nicholls State | L | 52-21 |
| NCAAF | 2022/09/17 19:00 | Nicholls State v SE Missouri St | L | 16-42 |