Round: 1
| NCAAF | 2022/09/10 17:00 | Mississippi College Choctaws v Keiser University Seahawks | L | 26-8 |
| NCAAF | 2022/09/17 23:00 | Lindenwood v Keiser University Seahawks | L | 37-3 |
| NCAAF | 2022/09/10 17:00 | Mississippi College Choctaws v Keiser University Seahawks | L | 26-8 |
| NCAAF | 2022/09/01 23:00 | Valdosta State v Keiser University Seahawks | L | 36-21 |
| NCAAF | 2022/11/12 20:00 | Mississippi College Choctaws v West Florida | L | 21-56 |
| NCAAF | 2022/11/05 19:00 | West Alabama Tigers v Mississippi College Choctaws | L | 38-16 |
| NCAAF | 2022/10/29 23:00 | Mississippi College Choctaws v Delta State | L | 38-52 |
| NCAAF | 2022/10/22 21:00 | West Florida v Mississippi College Choctaws | L | 45-17 |
| NCAAF | 2022/10/15 19:00 | Valdosta State v Mississippi College Choctaws | W | 40-49 |
| NCAAF | 2022/10/08 19:00 | Mississippi College Choctaws v Shorter Hawks | W | 35-21 |
| NCAAF | 2022/10/01 22:00 | West Georgia Wolves v Mississippi College Choctaws | W | 38-39 |
| NCAAF | 2022/09/25 00:00 | McNeese State v Mississippi College Choctaws | L | 32-17 |