| NCAAF FCS | 11/10 19:00 | 1 | South Dakota St v Southern Illinois | L | 57-38 | |
| NCAAF FCS | 11/03 18:00 | 1 | Western Illinois v Southern Illinois | L | 34-31 | |
| NCAAF | 10/27 19:00 | 1 | Missouri St v SO Illinois | W | 35-49 | |
| NCAAF | 10/20 19:00 | 1 | SO Illinois v Indiana State | L | 21-24 | |
| NCAAF | 10/13 19:00 | 1 | Southern Illinois v Illinois St | L | 3-51 | |
| NCAAF | 10/06 22:00 | 1 | Southern Illinois v Youngstown St | L | 14-17 | |
| NCAAF | 09/29 23:00 | 1 | South Dakota v Southern Illinois | L | 31-24 | |
| NCAAF | 09/15 23:00 | 1 | SE Missouri State v Southern Illinois | L | 48-44 | |
| NCAAF | 09/08 20:00 | 1 |
SO Illinois
v
Mississippi
|
L | 41-76 | |
| NCAAF | 08/30 23:00 | 1 | Southern Illinois v Murray St | W | 49-10 | |
| NCAAF | 11/18 19:00 | 1 | Western Illinois v SO Illinois | L | 28-14 | |
| NCAAF | 11/11 19:00 | 1 | SO Illinois v Youngstown State | L | 20-28 | |
| NCAAF | 11/04 18:00 | 1 | SO Illinois v Missouri St | L | 28-36 | |
| NCAAF | 10/28 20:00 | 1 | South Dakota v SO Illinois | L | 42-0 | |
| NCAAF | 10/21 19:00 | 1 | Indiana State v SO Illinois | W | 24-45 | |
| NCAAF | 10/14 19:00 | 1 | SO Illinois v Illinois State | W | 42-7 | |
| NCAAF | 10/07 23:00 | 1 | South Dakota State v SO Illinois | L | 49-14 | |
| NCAAF | 09/30 23:00 | 1 | SO Illinois v Northern Iowa | L | 17-24 | |
| NCAAF | 09/24 00:00 | 1 |
SO Illinois
v
Memphis
|
L | 31-44 | |
| NCAAF | 09/16 23:00 | 1 | SE Missouri St v SO Illinois | W | 17-35 | |
| NCAAF | 09/09 23:00 | 1 | SO Illinois v Mississippi Valley State | W | 55-3 | |
| NCAAF | 09/03 22:00 | 1 |
Florida Atlantic
v
SO Illinois
|
L | 38-30 | |
| NCAAF | 09/05 20:00 | 1 |
Indiana
v
SO Illinois
|
L | 48-47 | |
| NCAAF | 09/20 16:00 | 1 |
Purdue
v
SO Illinois
|
L | 35-13 | |
| NCAAF | 09/08 12:00 | 1 | Miami Ohio v SO Illinois | L | 30-14 | |
| NCAAF | 09/10 12:00 | 1 |
Mississippi
v
SO Illinois
|
L | 42-24 | |
| NCAAF | 09/11 12:00 | 1 |
Illinois
v
SO Illinois
|
L | 35-3 | |
| NCAAF | 09/05 12:00 | 1 |
Marshall
v
SO Illinois
|
L | 31-28 | |
| NCAAF | 09/13 12:00 | 1 |
Northwestern
v
SO Illinois
|
L | 33-7 | |
| NCAAF | 09/08 12:00 | 1 |
Northern Illinois
v
SO Illinois
|
W | 31-34 |